Bromin derivative of phtkalimid and process of making same



retest .lUlllllS BREDT, F AIX-l'lA-CHAPELLE, GERMANY, ASSIGNOR TO THE FAR BENFABRIKEN OF ELBERFELD COMPANY, OF NE YORK.

BRUlVllN DERIVATIVE 0F PHTHALiMlD AND PROCESS Ol MAKING SAME! s'rncrr'zc'arron? forming part at Letters Eatent not 621,319, dated March 21, 1899. Application filed Jilly 30,1898. Serial not 687,255. on specimens-l 00 o n Nl3r C0 This process consists in general in treating the alkaline salts of phtalimid with bromin. According to my researches this new com pound exhibits in a high degree bacterlcideproperties and represents, therefore, a valuable remedy for skin diseases and is intended to be used as a dusting-powde13 Etc.

In carrying out my invention practically I 2 5 can proceed as follows; the parts being by weight:) Twenty parts of phtalimid are dissolved by means of 6.4parts of sodium hydrate and sixty parts of water. The resdlting solution is stirred into an icy-cold mixture of 21.7

parts of bromin with two hundred parts of water. The new brominated derivative separates during this operation." lVhen the whole alkaline solution of phtalimid has been added,

the precipitate is filtered off, Washed with ice 3 5 water, and dried at low temperatures.

be further purified by recrystallization from chloroform or benzene. v

\Vhcn recrystallized from benzene, the new product represents a White crystalline powder which when heated in a capillary tube begins to liqucfiy at about 180 centigrade and melts completely at from 206 to 207 centigradel If the new product is strongly heated, it is decomposcd under evolution of bromin, while by the action of warm water it is decomposed according to the following equation:

My invention relates to the production olfltcanc co o n/ NBr+I-l0ll-: v co phtalimid and hypobromic acid {BrOll} be ing thus formed.

- Iaving now described my invention and in whatmanner the same istohe performed, what I claim as new, and desire to secure by Letters Patent, is-- 1. The process for producing a new bromi 6 nated derivative from phtalimid which has the formula which process consists in first dissolving phtalheated, yielding phtalimid and hypobromic acid when. treated with warm water and adapted fo'r use against skin diseases. In testimony whereof I have signed my name in the presence of two subscribing wilt nesses.

' I r-lULIl- S illilflllii.

Witnesses:

JoHN llscmmnss,

FRANK M. BRUNDAGE. 

